Results 81 to 90 of about 168,982,903 (290)

Care coordination of multimorbidity: a scoping study [PDF]

, 2015
Background: A key challenge in healthcare systems worldwide is the large number of patients who suffer from multimorbidity; despite this, most systems are organized within a single-disease framework. Objective: The present study addresses two issues: the
Burau, Viola, Doessing, Anne, Anne Doessing, Viola Burau   +3 more
core   +1 more source

Conflict of Interests of the Council of Europe, EU and Russia in the Sphere of Protection of Human Rights and Promotion of Democracy

RUDN Journal of Political Science, 2016
The article considers the interaction of the Council of Europe, EU and Russia in the sphere of the protection of human rights and the promotion of democracy.
M V Danilina
doaj  

Space Efficiency of Transit-Oriented Station Areas: A Case Study from a Complex Adaptive System Perspective

ISPRS International Journal of Geo-Information
Transit-oriented development (TOD) has been widely adopted in urban planning to alleviate traffic congestion, urban sprawl, and other problems. The TOD metro station area, as a dynamic and open spatial system, presents typical complex features.
Jinwen Fan, Zhenwu Shi, Jie Liu, Jinru Wang   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The open method of co-ordination and the analysis of mutual learning processes of the European employment strategy [PDF]

The purpose of this paper is to address two normative and interlinked methodological and theoretical questions concerning the Open Method of Coordination (OMC): First, what is the most appropriate approach to learning in the analyses of the processes of ...
Nedergaard, Peter
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Research on Adaptive Cycle Engine Mode Transition Control Method

Energies
Mode transition is an important dynamic process of an adaptive cycle engine (ACE). In order to obtain a smooth mode transition process, the closed-loop controller is designed based on the strong robust augmented linear quadric regulator (ALQR) method ...
Xingyu Zhao, Qiuhong Li, Shuwei Pang, Zhaohui Xue, Daming Deng, Feng Lu   +5 more
doaj   +1 more source

Analisis Komunikasi Internal dan Kinerja Karyawan di UMKM Mirukiway Bandung

Jurnal Manajemen dan Bisnis Kreatif
This study aims to examine internal communication and its impact on employee performance at UMKM Mirukiway Bandung. The research employs a qualitative approach with a case study method, collecting data through in-depth interviews and analyzing them ...
Donni Junipriansa, Nabil Ar Araaf, Savira Najwa   +2 more
doaj   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source