Results 101 to 110 of about 2,192,791 (336)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

An Interview with Aaron Barlow, editor of Academe, the magazine of the American Association of University Professors

open access: yesNANO, 2014
Aaron Barlow shares his views with Sean Scanlan on the problems of traditional peer review. Barlow is Faculty Editor of Academe, the magazine of the American Association of University Professors (AAUP).
Sean Scanlan, Aaron Barlow
doaj  

Open peer review urgently requires evidence: A call to action. [PDF]

open access: yesPLoS Biol, 2023
Ross-Hellauer T   +2 more
europepmc   +1 more source

Open Access and Open Assessment: The Future of Peer Reviewed Journals? Experiences with a New Journal in Economics [PDF]

open access: yes, 2009
Open Access Journals have become more and more popular as a publishing model for academic scholars. There are already more than 3,500 of them listed in the Directory of Open Access Journals (DOAJ).
Siegert, Olaf, Werner-Schwarz, Korinna
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Research Integrity and Peer Review—past highlights and future directions

open access: yesResearch Integrity and Peer Review, 2018
In May 2016, we launched Research Integrity and Peer Review, an international, open access journal with fully open peer review (reviewers are identified on their reports and named reports are published alongside the article) to provide a home for ...
Stephanie L. Boughton   +4 more
doaj   +1 more source

Open peer review: bringing transparency, accountability, and inclusivity to the peer review process [PDF]

open access: yes, 2017
Open peer review is moving into the mainstream, but it is often poorly understood and surveys of researcher attitudes show important barriers to implementation.
Ross-Hellauer, Tony
core  

Home - About - Disclaimer - Privacy