Results 151 to 160 of about 165,562 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

From private office to locker room: how corporate America is transforming academic family medicine. [PDF]

Front Med (Lausanne)
Schmidt SOF, Sanders EC, Orlando FA.
europepmc   +1 more source

Lighting of open plan (automated) offices

, 2016
Cataloged from PDF version of article.
openaire   +2 more sources

An acoustical evaluation model for open plan offices

, 2021
In this study roles of the architectural and acoustical parameters, which influences acoustics of open plan offices are examined. The first point to be considered during the design process of the open plan offices is privacy. Articulation index would be the unit of privacy.
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Workstation design for the open-plan office

, 2004
Well-designed workstations in an open-plan office will assure a comfortable, satisfying working environment for occupants. This Update reviews some of the key design issues and provides guidance for achieving a successful outcome, based on research ...
Veitch, J. A., Newsham, G. R., Charles, K. E.   +2 more
core  

Correction: Fermentation bed farming improves behavioral expression and stress resistance in geese. [PDF]

Front Vet Sci
Li H, Yang J, Zhang J, Zhao L, Zhou T, Chen H, Li J, Zhao S, Yin G.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Study of the Acoustic Suitability of an Open Plan Office Based on STI and DL2 Simulations

, 2012
Many business offices around the world are organized as open plan offices. Therefore, studies about the acoustic comfort of the people who work in them have become increasingly important.
Zannin, P. H. T., Passero, C. R. M.
core