Results 91 to 100 of about 821,108 (309)

Evidence-Based Design: Theoretical and Practical Reflections of an Emerging Approach in Office Architecture [PDF]

open access: yes, 2009
Evidence-based design is a practice that has emerged only relatively recently, inspired by a growing popularity of evidence-based approaches in other professions such as medicine.
Budgen, Andrew   +4 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

WRI's Governance Strategy, 2016-2020 [PDF]

open access: yes, 2016
Transparent, effective, accountable governance is critical to ensuring that development benefits people and the planet. The Governance Center of Excellence works with civil society, governments, development agencies, businesses, and other institutions to

core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Noise Pollution Effects on Mental Fatigue and Noise Annoyance among Bank Staffs

open access: yesInternational Journal of Occupational Hygiene, 2019
Noise discomfort is one of the important unpleasant physical parameters in open-plan offices. This study was aimed to investigate the status of noise pollution and its effects on subjective fatigue and noise annoyance among bank staffs.
Mohammad Reza Zare   +4 more
doaj  

Thermal Comfort and Adaptive Occupant Behaviour in Open Plan Offices in India and Lithuania

open access: yesBuildings
Understanding the relationship between thermal comfort and adaptive behaviour in office environments is important for designing sustainable and occupant-centric buildings.
Himanshu Patel Tuniki   +4 more
doaj   +1 more source

Does the Number of Occupants in an Office Influence Individual Perceptions of Comfort and Productivity?—New Evidence from 5000 Office Workers

open access: yesBuildings, 2019
Purpose—The purpose of this article is to present evidence of occupants’ perception of their work environment in five different office types (Solo, Duo, 2–4, 5–8 and 8Plus offices).
Eziaku Onyeizu Rasheed   +2 more
doaj   +1 more source

The Performance of Natural Ventilation In A Dance Studio – Lessons From Tracer Gas Measurements And Control Integration [PDF]

open access: yes, 2015
The naturally ventilated, three storey School of Arts Jarman Building provides two dance studios, an exhibition gallery, teaching rooms, video editing suites and offices.
Giridharan, R.   +3 more
core  

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