Results 111 to 120 of about 821,108 (309)

Explaining the influence of biophilic design on employee well-being

Scientific Reports
Biophilic workplace design has been proposed as an effective strategy to increase employee well-being in open-plan offices. To expand our understanding of why and for whom indoor nature exposure increases well-being, the aim of this study was to evaluate
Carmen Valor, Raquel Redondo, Isabel Carrero   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Localized lighting in open-plan offices

, 2016
Controlling lighting conditions at desk level has proven its energy savings potential. However, in open-plan offices without partitions separating desks this local control might come at expense of users’ comfort. An explorative study in an office building in the Netherlands revealed the influence of local control on users’ satisfaction with the ...
de Bakker, C., Aries, M.B.C., Kort, H.S.M., Rosemann, A.L.P.   +3 more
openaire   +1 more source

Evidence-based design: theoretical and practical reflections of an emerging approach in office architecture [PDF]

, 2008
Evidence-based design is a practice that has emerged only relatively recently, inspired by a growing popularity of evidence-based approaches in other professions such as medicine.
Budgen, A., Lonsdale, N., Penn, A., Sailer, K., Turner, A.   +4 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Does job control contribute to differences in physician-certified sickness absence across office concepts? A mediation analysis in a nationally representative sample

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: Several studies have found higher sickness absence in shared and open workspaces than in private offices, but little is known about why these differences occur.
Randi Hovden Borge, Håkon A Johannessen, Knut Inge Fostervold, Morten Birkeland Nielsen   +3 more
doaj   +1 more source

Comparative studies of offices pre and post — how changing spatial configurations affect organisational behaviours [PDF]

, 2009
Understanding the way in which design interventions in an office affect everyday users, and thus shape organisational behaviour, should be high on the agenda for architects, designers and consultants alike. Surprisingly, this seems rarely to be the case.
Budgen, A., Lonsdale, N., Penn, A., Sailer, K., Turner, A.   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

China Employment Law Guide [PDF]

, 2005
[Excerpt] This guide comments on the general rules applicable under national Chinese laws and regulations, and the numerous local regulations, rules and practices that continually play a fundamental role in the application of law in China in each case ...
Baker & McKenzie
core   +1 more source