Results 121 to 130 of about 821,108 (309)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Coworking Spaces – A Source for Developing Creative Business [PDF]

Ovidius University Annals: Economic Sciences Series, 2019
The effects of information technology have allowed people to choose between working at the firm's office, home office or in collaborative spaces, in open plan office environments, where they work alongside other non-affiliated professionals for a monthly
Claudia Isac
doaj  

Longley Building: Reuse and Rehabilitation Feasibility Report [PDF]

, 2012
The southern, eastern, and northern façades (the principal façades) have a great amount of decorative masonry including granite, slate coursing, brownstone coursing, and brick veneer (Photo 2). All of these materials are in good condition, except for the
DeBlock, Elizabeth, Dermody, Robert, LeBlanc, Alexander, Marshal, Philip, Reid, Carolyn, Robinson, Arnold, Wilson, Kathleen   +6 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

EFEITO DA REESTRUTURAÇÃO DO AMBIENTE DE TRABALHO SOBRE A SAÚDE DE TRABALHADORES ADMINISTRATIVOS: IMPLANTAÇÃO DE OPEN-PLAN OFFICES

Ação Ergonômica, 2015
O trabalho em equipe tem sido cada vez mais incentivado, refletindo até mesmo na organização do ambiente ocupacional. Objetivando facilitar a interação tem-se observado adaptações ambientais na substituição de salas individuas por open-plan offices. Este
Gabriela Salomé Nunes, Amanda Magdalena Ferroli, Raísa Marques de Sousa, Michele Elisabete Rubio Alem, Roberta de Fátima Carreira Moreira, Cristiane Shinohara Moriguchi   +5 more
doaj  

Understanding user evaluation structures for wooden frames in open-plan offices: a quantitative and qualitative study

Journal of Wood Science
This study aimed to explore the psychological effects of wooden frames and interiors in open-plan offices (OPO) and to understand the evaluation structure associated with wooden materials.
Takashi Shima, Katsuhiko Sakata, Mayu Shirakawa, Yuko Tsunetsugu   +3 more
doaj   +1 more source

A systematic investigation of group differences in crossed effects of indoor environmental parameters on human comfort in open-plan offices in severe cold regions

Developments in the Built Environment
This study examined group differences in the crossed effects of indoor environmental parameters on human comfort in open-plan offices in severe cold regions, considering gender, age, education, BMI and seating location.
Zheng Li, Guoqing Song, Qingwen Zhang, Yuliang Liu, Jiangtao Yu, Feng Fan   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source