Results 111 to 120 of about 1,812,344 (297)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Chapter 4: New Assessment Methods [PDF]

open access: yes, 2000
The OTiS (Online Teaching in Scotland) programme, run by the now defunct Scotcit programme, ran an International e-Workshop on Developing Online Tutoring Skills which was held between 8–12 May 2000.

core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Energy Efficiency in Open RAN: RF Channel Reconfiguration Use Case

open access: yesIEEE Access
Recently, energy efficiency (EE) has been pointed out as one of the key requirements within mobile networks. The development of intelligent algorithms providing Radio Access Networks (RAN) with EE features is possible when having access to the Key ...
Marcin Hoffmann, Marcin Dryjanski
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

High-Throughput Accelerator for Exact-MMSE Soft-Output Detection in Open RAN Systems

open access: yesIEEE Access
Open Radio Access Networks (Open RANs), realized fully in software, require excessive computing resources to support time-sensitive signal-processing algorithms in the physical layer.
Thomas James Thomas   +1 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Adapting LoRaWAN to the Open-RAN Architecture

open access: yesIEEE Network
This article proposes O-LoRaWAN, an adaptation of the LoRaWAN architecture into a modular network architecture based on the Open RAN (O-RAN) principles. In our vision, standardization of the network components and interfaces will enable the reuse of network functions, and thus, foster an accelerated tailoring of the network functions to the changing ...
Sobhi Alfayoumi   +2 more
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

RAN Virtualization: How Hard Is It to Fully Achieve?

open access: yesIEEE Access
Radio Access Network (RAN) virtualization stands as a pivotal concept in the realm of 5G networks and beyond. It emerges as a viable solution not only to address energy cost concerns but also to optimize material and radio resource management.
Mihia Kassi, Soumaya Hamouda
doaj   +1 more source

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