Nature Communications, 2019 It is challenging to characterize diverse transcript isoforms by short-read sequencing. Here the authors report full-length transcriptomes in rat hippocampus by hybrid-sequencing, predict isoform-specific translational status, and reconstruct open ...
Xi Wang +15 more
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Translation of upstream open reading frames in a model of neuronal differentiation
BMC Genomics, 2019 Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside.
Caitlin M. Rodriguez +3 more
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The identification of conserved sequence features of co‐translationally decayed mRNAs and upstream open reading frames in angiosperm transcriptomes [PDF]
, 2023 Rong Guo, Xiang Yu, Brian D. Gregory
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HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Filtering "genic" open reading frames from genomic DNA samples for advanced annotation
BMC Genomics, 2011 Background In order to carry out experimental gene annotation, DNA encoding open reading frames (ORFs) derived from real genes (termed "genic") in the correct frame is required.
Sblattero Daniele +6 more
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Immunogenicity and Protective Response Induced by Recombinant Plasmids Based on the BAB1_0267 and BAB1_0270 Open Reading Frames of Brucella abortus 2308 in BALB/c Mice [PDF]
, 2016 Leonardo A. Gómez +6 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin +12 more
wiley +1 more source
Quantitative sequence and open reading frame analysis based on codon bias [PDF]
Journal of Systemics, Cybernetics and Informatics, 2006 The frequencies with which the sixty-four codons occur in human coding DNA are known. If we assume that the codons occur randomly, subject only to these probabilities, then it is possible to predict trinucleotide frequencies in each of the five other ...
Susan Rainey, Joe Repka
doaj
MetamORF: a repository of unique short open reading frames identified by both experimental and computational approaches for gene and metagene analyses [PDF]
, 2021 Sébastien A. Choteau +4 more
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Citation: 'open reading frame' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09713 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source