Results 101 to 110 of about 162,248 (282)

Hundreds of putatively functional small open reading frames in [PDF]

, 2011
Background: The relationship between DNA sequence and encoded information is still an unsolved puzzle. The number of protein-coding genes in higher eukaryotes identified by genome projects is lower than was expected, while a considerable amount of ...
Adam Eyre-Walker, Emmanuel Ladoukakis (267473), Juan Pablo Couso (4460890), Adam Eyre-Walker (4460752), Vini Pereira, Emile G Magny (16134404), Emile G Magny, Juan Couso, Emmanuel Ladoukakis, Vini Pereira (6325)   +9 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Pervasive functional translation of noncanonical human open reading frames [PDF]

, 2020
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based screening strategy to identify hundreds of noncanonical CDSs that are ...
Mann, Matthias, Cogan, J Zachery, Chen, Jin, Nuñez, James K, Brunner, Andreas-David, Itzhak, Daniel N, Leonetti, Manuel D, Li, Jason Y, Adamson, Britt, Weissman, Jonathan S, Fields, Alexander P   +10 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Translational buffering by ribosome stalling in upstream open reading frames [PDF]

, 2023
Thesis (Ph.D.)--University of Washington, 2023Upstream open reading frames (uORFs) are present in over half of all human mRNAs. uORFs can potently regulate the translation of downstream open reading frames through several mechanisms: siphoning away ...
Bottorff, Ty
core  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Characterization of new proteins found by analysis of short open reading frames from the full yeast genome [PDF]

, 1997
peer reviewedWe have analysed short open reading frames (between 150 and 300 base pairs long) of the yeast genome (Saccharomyces cerevisiae) with a two-step strategy. The first step selects a candidate set of open reading frames from the DNA.
Casari, G., Sander, C., SCHNEIDER, Reinhard, Daruvar, A., Andrade, M. A., Termier, M.   +5 more
core  

Maximum-Likelihood phylogenetic tree showing relationship distances obtained by comparing CCHFV M- and L-segment open-reading frames. [PDF]

, 2016
Maximum-Likelihood phylogenetic tree showing relationship distances obtained by comparing CCHFV M- and L-segment open-reading frames.
Stuart D. Dowall (534412), Roger Hewson (288208), David N. Bukbuk (3385823), Barry Atkinson (2697406), Kuiama Lewandowski (3385829), Saka S. Baba (3385826), Andrew Bell (4774), Andrew Bosworth (2697403), Anitha Varghese (3385832), Robert J. Watson (1343463)   +9 more
core   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source