Results 81 to 90 of about 162,248 (282)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Proposed functions of open reading frames in the zeamine biosynthetic gene cluster region. [PDF]

, 2013
Proposed functions of open reading frames in the zeamine biosynthetic gene cluster region.
Jef Rozenski (57476), Abram Aertsen (43457), Chris Lamberigts (102431), Piet Herdewijn (8001), Chris Michiels (102452), Birgit Uytterhoeven (102426), Rob Van Houdt (102422), Eveline Lescrinier (7999), Wesley Mattheus (102410), Ling-Jie Gao (102414), Pieter Moons (102418), Rob Lavigne (102459), Joleen Masschelein (102407)   +12 more
core   +1 more source

Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Nature Communications, 2021
Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how ...
Hong Zhang, Yirong Wang, Xinkai Wu, Xiaolu Tang, Changcheng Wu, Jian Lu   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Pectinolytic Enzymes: Open Reading Frames (ORFs) present in the Xcc, Xac and Xoo genomes. [PDF]

, 2016
Pectinolytic Enzymes: Open Reading Frames (ORFs) present in the Xcc, Xac and Xoo genomes.
Hitendra Kumar Patel (463535), Roshan V. Maku (3374435), Lavanya Tayi (3374438), Ramesh V. Sonti (463536)   +3 more
core   +1 more source

Author Correction: Evolutionary divergence of novel open reading frames in cichlids speciation

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Shraddha Puntambekar, Rachel Newhouse, Jaime San-Miguel, Ruchi Chauhan, Grégoire Vernaz, Thomas Willis, Matthew T. Wayland, Yagnesh Umrania, Eric A. Miska, Sudhakaran Prabakaran   +9 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Primers used for full length amplification of the carrier open reading frames. [PDF]

, 2013
Primers used for full length amplification of the carrier open reading frames.
Katharina Bakhaus (411335), Daniela Fietz (411334), Christina E. Galuska (411341), Gary Grosser (411337), Wolfgang Weidner (108055), Martin Bergmann (108053), Sabine Kliesch (223438), Britta Wapelhorst (411336), Jörg Alber (411339), Stefan A. Wudy (411343), Barbara Döring (411340), Sabine Günther (411338), Joachim Geyer (411344), Michaela F. Hartmann (411342)   +13 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

2 - Bioinformatic analysis of Insect Iridescent Virus (IIV6) proposes novel open reading frames and supports previously described putative protein products [PDF]

, 2018
Bioinformatic analysis of Insect Iridescent Virus (IIV6) proposes novel open reading frames and supports previously described putative protein products Amanda D. Mileham, and Amanda L.J.
Mileham, Amanda D.
core   +1 more source