Results 61 to 70 of about 159,413 (329)
, 2016 The Bridger assembly produced the most amount of open reading frames for sequences with >799 bps (red), >999 bps (blue), and >1,199 bps (green).
Carolyn S. Bentivegna (2602489) +4 more
core +1 more source
Disrupting upstream translation in mRNAs is associated with human disease
Nature Communications, 2021 The significance of translated upstream open reading frames is not well known. Here, the authors investigate genetic variants in these regions, finding that they are under high evolutionary constraint and may contribute to disease.
David S. M. Lee +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Enrichment of open reading frames presented on bacteriophage M13 using Hyperphage
BioTechniques, 2006 The enrichment of open reading frames (ORFs) from large gene libraries and the presentation of the corresponding polypeptides on filamentous phage M13 (phage display) is frequently used to identify binding partners of unknown ORFs.
Michael Hust +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Проблемы особо опасных инфекций, 2015 Identified are the complete nucleotide sequences of two cryptic plasmids - pCKF from the Central-Caucasian high-mountain plague focus and pTP33 - from Tuva mountain plague focus in Russia. It is established that the size of the pCKF is 5.4 kbp, and its G-
E. G. Oglodin +6 more
doaj +1 more source
Open reading frames of unknown function.
, 2013 Open reading frames of unknown function.
Andreas Mayer (187816) +1 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Genomic Signals of Reoriented ORFs
EURASIP Journal on Advances in Signal Processing, 2004 Complex representation of nucleotides is used to convert DNA sequences into complex digital genomic signals. The analysis of the cumulated phase and unwrapped phase of DNA genomic signals reveals large-scale features of eukaryote and prokaryote ...
Paul Dan Cristea
doaj +1 more source
Small Open Reading Frames: Current Prediction Techniques and Future Prospect
, 2011 Evidence is accumulating that small open reading frames (sORF,
Chan, Wai Soon +11 more
core +1 more source