Results 51 to 60 of about 159,413 (329)
, 2023 peer reviewedProteomic diversity in biological samples can be characterized by mass spectrometry (MS)-based proteomics using customized protein databases generated from sets of transcripts previously detected by RNA-seq.
Roucou, Xavier +9 more
core +3 more sources
, 2021 Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We leveraged the power of systems-level comparative transcriptome analysis in human tissues to discover genes associated with brain metastasis in human breast cancer by ...
Shahan Mamoor
core +1 more source
Gene expression regulation by upstream open reading frames and human disease. [PDF]
PLoS Genetics, 2013 Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryotic mRNAs, one or more uORFs precede the initiation codon of the main coding region.
Cristina Barbosa +2 more
doaj +1 more source
Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq
eLife, 2014 Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still unclear.
Julie L Aspden +6 more
doaj +1 more source
Almespar: An Open Reading Frames Detection Tool Using Python
, 2023 Background and aims. Open reading frames (ORFs) are sections of a reading frame that do not include any stop codons. A reading frame is a sequence of nucleotide triplets read as codons indicating amino acids; a single strand of DNA has three potential ...
Osamah Alrouwab1,2 * , Ismail Mallian1, Buthaynah Ramadhan2, Kareemah Abdullah2, Omiema Aznad2, Abd Almajid Abu khashim3, Mahmoud Gargotti4
core +1 more source
Biochemical and Biophysical Research Communications, 2000 The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from exon 2.
Schluter, G. +2 more
openaire +3 more sources
Maintenance of the correct open reading frame by the ribosome [PDF]
EMBO reports, 2003 During translation, a string of non‐overlapping triplet codons in messenger RNA is decoded into protein. The ability of a ribosome to decode mRNA without shifting between reading frames is a strict requirement for accurate protein biosynthesis.
Thomas M, Hansen +4 more
openaire +2 more sources
uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.
PLoS ONE, 2019 Ribosome profiling (ribo-seq) provides a means to analyze active translation by determining ribosome occupancy in a transcriptome-wide manner. The vast majority of ribosome protected fragments (RPFs) resides within the protein-coding sequence of mRNAs ...
Anica Scholz +7 more
doaj +1 more source
Viruses, 2023 Bacteriophage genomes represent an enormous level of genetic diversity and provide considerable potential to acquire new insights about viral genome evolution. In this study, the genome sequences of sixteen Bacillus-infecting bacteriophages were explored
Ahmed Ismail +6 more
doaj +1 more source
Mini-Exon Epitope Tagging for Analysis of the Protein Coding Potential of Genomic Sequence
BioTechniques, 1997 A novel approach to gene discovery and analysis is described. A small exon flanked by consensus 3′ and 5′ splice sites was synthesized. The exon contains open reading frames encoding 43 amino acid peptides.
Desmond J. Smith
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