Results 71 to 80 of about 162,248 (282)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Simultaneous cloning of open reading frames into several different expression vectors
BioTechniques, 2003 Genomic sequencing has enabled the prediction of thousands of genes, most of which either cannot be assigned a function or can be only broadly categorized on the basis of sequence alone.
Clement A. Stanyon +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Expression of Open Reading Frames in Fn U112. [PDF]
, 2016 Expression of predicted genes (open reading frames) in Fn U112 genome. Genes in the outer circle are on the plus strand while those in the inner circle are on the minus strand.
Robert H. Waldo (3045141) +3 more
core +1 more source
John Pier, Configurazioni narrative
Enthymema, 2009 The article moves in the direction of an intertextual narratology integrating semiotic reflection with logic, focusing on the concept of “configuration” as model of comprehension (Mink, Ricoeur).
Alessandra Diazzi
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Comparison of the putative open reading frames (ORFs) of ϕAB6 with ϕAB1. [PDF]
, 2016 Comparison of the putative open reading frames (ORFs) of ϕAB6 with ϕAB1.
Kai-Chih Chang (279688) +6 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Gene expression regulation by upstream open reading frames in rare diseases [PDF]
, 2017 Upstream open reading frames (uORFs) constitute a class of cis-acting elements that regulate translation initiation. Mutations or polymorphisms that alter, create or disrupt a uORF have been widely associated with several human disorders, including ...
Fernandes, Rafael +2 more
core
Journal of Integrative Bioinformatics, 2009 Metabolic models have the potential to impact on genome annotation and on the interpretation of gene expression and other high throughput genome data. The genome of Streptomyces coelicolor genome has been sequenced and some 30% of the open reading frames
Saqi Mansoor +4 more
doaj +2 more sources