Results 241 to 250 of about 162,248 (282)

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins

Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis A, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Hubner N, Ingolia NT, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Rackham O, Roucou X, Slavoff SA, Valen E, Wacholder A, Weissman JS, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Moritz RL, Prensner JR, van Heesch S.   +42 more
europepmc   +1 more source

Coupling of Open Reading Frames by Translational Bypassing [PDF]

Annual Review of Biochemistry, 2000
▪ Abstract  Translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. The underlying mechanism centers on the decoding properties of peptidyl-transfer RNA (tRNA) and involves three stages: take-off, scanning, and landing.
A J, Herr, J F, Atkins, R F, Gesteland
openaire   +3 more sources

Statistical properties of open reading frames in complete genome sequences [PDF]

Computers & Chemistry, 1999
Some statistical properties of open reading frames in all currently available complete genome sequences are analyzed (seventeen prokatyotic genomes, and 16 chromosome sequences from the yeast genome).
Wentian Li
exaly   +1 more source

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The Definition of Open Reading Frame Revisited

Trends in Genetics, 2018
The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.
Patricia Sieber, Matthias Platzer, Stefan Schuster   +2 more
openaire   +2 more sources

Translational Control via Protein-Regulated Upstream Open Reading Frames [PDF]

Cell, 2011
SummaryAnalysis of the regulation of msl-2 mRNA by Sex lethal (SXL), which is critical for dosage compensation in Drosophila, has uncovered a mode of translational control based on common 5′ untranslated region elements, upstream open reading frames ...
Matthias Hentze, Markus Seiler, Jan Medenbach   +2 more
exaly   +2 more sources

Inferring genes from open reading frames

Computers & Chemistry, 1994
One expects that in DNA without protein coding function, stop codons (which constitute three of the 64 possible codons) should occur frequently in all reading frames, and that a long open reading frame (ORF) can be interpreted as a sign for the existence of a gene.
openaire   +2 more sources

Bioprospecting Open Reading Frames for Peptide Effectors

2013
Recent successes in the development of small-molecule antagonists of protein-protein interactions designed based on co-crystal structures of peptides bound to their biological targets confirm that short peptides derived from interacting proteins can be high-value ligands for pharmacologic validation of targets and for identification of druggable sites.
Ling, Xiong, Charles, Scott
openaire   +2 more sources