Results 81 to 90 of about 70,104,016 (248)

Research protocol of two concurrent cluster-randomized trials: Real-life Effect of a CAMPaign with Measles Vaccination (RECAMP-MV) and Real-life Effect of a CAMPaign with Oral Polio Vaccination (RECAMP-OPV) on mortality and morbidity among children in rural Guinea-Bissau

BMC Public Health, 2019
Background Measles and oral polio vaccinations may reduce child mortality to an extent that cannot be explained by prevention of measles and polio infections; these vaccines seem to have beneficial non-specific effects.
A. Varma, A. K. G. Jensen, S. M. Thysen, L. M. Pedersen, P. Aaby, A. B. Fisker   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Open Research Data

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2014
Open Research Data - A step by step guide through the research data lifecycle, data set creation, big data vs long-tail, metadata, data centres/data repositories, open access for data, data sharing, data citation and publication.
Sarah Callaghan
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Open education and educational resources. National policy and executive plan by the higher education and research community for 2021-2025: Policy component 1 – Open access to educational resources [PDF]

, 2020
The policy is composed of joint principles and policy components of (a) open access to educational resources and (b) open educational practices that determine objectives and actions.
Open Science and Research Coordination
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Open Practices in Phytolith Research: A Community Survey

Open Quaternary
The open research movement has gained momentum in the last decade and no academic can ignore the necessity to make research more open, as it improves reliability, sustainability and reusability of data.
Javier Ruiz-Pérez, Emma Karoune, Céline Kerfant, Juan José García-Granero, Marco Madella, Carla Lancelotti   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

It Takes a Village! Editorship, Advocacy, and Research in Running an Open Access Data Journal

Publications
Partaking in the editorial process of an academic journal is both a challenging and rewarding experience. It takes a village of dedicated individuals with a vested interest in the dissemination and sharing of high-quality research outputs.
Mandy Wigdorowitz, Marton Ribary, Andrea Farina, Eleonora Lima, Daniele Borkowski, Paola Marongiu, Amanda H. Sorensen, Christelle Timis, Barbara McGillivray   +8 more
doaj   +1 more source