Results 221 to 230 of about 4,459,857 (276)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Blind Challenges Let Us See the Path Forward for Predictive Models. [PDF]

J Chem Inf Model
Chodera JD, Walters WP, Kosuri S, Fraser JS.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Decision-Making Under Model Misspecification: DRO with Robust Bayesian Ambiguity Sets. [PDF]

Entropy (Basel)
Dellaporta C, O'Hara P, Damoulas T.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Universal dense-open windows for generic conservative surface semigroups and graph-directed local systems

Shmalo Y.
europepmc   +1 more source

Yield Prediction of Organic Reactions in Biased Data Sets via Positive-Unlabeled Learning. [PDF]

J Am Chem Soc
Boser F, Spies JC, Glorius F.
europepmc   +1 more source

Machine learning-based radiomics analysis of PET imaging for early prediction of concurrent chemoradiotherapy response in stage II-III cervical squamous cell carcinoma. [PDF]

BMC Cancer
Pang D, Yang H, Zhang S, Qiu W, Pu W, Liu Z, Yang Z, Li N, Liao H, Xiao G.   +9 more
europepmc   +1 more source

Simplifying causal gene identification in GWAS loci. [PDF]

PLoS Genet
Schipper M, Ulirsch J, Posthuma D, Ripke S, Heilbron K.   +4 more
europepmc   +1 more source