Results 91 to 100 of about 23,553,956 (305)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Layer-Wise Personalized Federated Learning for Mobile Traffic Prediction

IEEE Access
With the evolution of mobile networks delivering high-performance network services to a myriad of devices, accurate mobile traffic prediction has become increasingly important.
Seungyeol Lee, Jihoon Sung, Myung-Ki Shin   +2 more
doaj   +1 more source

Opening the sources of accountability

First Monday, 2004
This paper scrutinizes the concept of accountability in light of free and open source software. On the view that increasing accountability grants value to society by motivating those most likely and able to prevent risk and harm to do so, I argue that while developing software collaboratively, licensing it openly, and distributing its source code ...
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

What is the “Source” of Open Source Hardware?

Journal of Open Hardware, 2017
What “open source” means once applied to tangible products has been so far mostly addressed through the light of licensing. While this approach is suitable for software, it appears to be over-simplistic for complex hardware products.
Jérémy Bonvoisin, Robert Mies, Jean-François Boujut, Rainer Stark   +3 more
doaj   +1 more source

Collaborative Development within Open Source Communities [PDF]

, 2008
Open source communities are one of the most successful-- and least appreciated--examples of high-performance collaboration and community building on the Internet today.
Soriano Camino, Francisco Javier, Javier Soriano, Sonia Frutos, Jiménez Gañán, Miguel, Frutos Cid, Sonia, null Jiménez. Miguel   +5 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Ivermectin in veterinary medicine: a narrative review of antiparasitic efficacy, resistance evolution, antiviral evidence, and One Health implications

Frontiers in Veterinary Science
Ivermectin is a common macrocyclic lactone that is proven to be active against a wide range of parasites in veterinary medicine. This article presents a narrative review that combines evidence on the antiparasitic effects of ivermectin, its therapeutic ...
Matthew T. J. Halma, Matthew T. J. Halma, Joseph Varon, Valeria Garcia, Sidra Hassaan, Jack Tuszynski, Jack Tuszynski   +6 more
doaj   +1 more source

Empirical studies of open source evolution [PDF]

, 2008
Copyright @ 2008 Springer-VerlagThis chapter presents a sample of empirical studies of Open Source Software (OSS) evolution. According to these studies, the classical results from the studies of proprietary software evoltion, such as Lehman’s laws of ...
Andrea Capiluppi, Fernandez-Ramil, Juan, Lozano, Angela, Wermelinger, Michel, Fernández-Ramil, J, Capiluppi, A, Wermelinger, M, Lozano, A, Juan Fernandez-Ramil, Capiluppi, Andrea, Capiluppi, Andrea; id_orcid, Michel Wermelinger, Angela Lozano   +12 more
core   +2 more sources