Results 111 to 120 of about 23,553,956 (305)
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Modifying the universe around us: the design act as transformative semiosis process .
InmaterialUnderlying the anthropocosmic conception of the philosopher Valery Nikolaevich Sagatovsky is the understanding of being as a unitary totality in which matter, soul and spirit are on an equal footing in terms of dignity and value.
Tiziano Manna
doaj
Addressing infectious diseases in Africa by accelerating drug discovery through data science
Communications MedicineDespite being rich in natural resources and scientific talent, Africa continues to bear a staggering infectious disease burden. Historically, health innovation on the continent has relied on international funding and has been constrained by limited ...
Gemma Turon +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Frontiers in MedicineThe National Academies of Science, Engineering, and Medicine (NASEM) has defined Long COVID as “an infection-associated chronic condition (IACC) that occurs after SARS-CoV-2 infection and is present for at least 3 months as a continuous, relapsing and ...
Matthew Halma +2 more
doaj +1 more source
An open source "open source internet research tool"
, 2016 Open Source Internet Research Toolkit (OSIRT) is an open source tool developed in C# to support officers conducting open source research on the Internet.
Williams, J.
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Why open source software can succeed [PDF]
The paper discusses three key economic problems raised by the emergence and diffusion of Open source software: motivation, coordination, and diffusion under a dominant standard.
Cristina Rossi, Andrea Bonaccorsi
core
OpenScienceMOOC/Module-5-Open-Research-Software-and-Open-Source: Second release
, 2018 <p>Second release. Now includes new file formats, new tasks, and more.</p> <p> </p> <p>Link to source material: <a href="https://github.com/OpenScienceMOOC/Module-5-Open-Research-Software-and-Open-Source"> ...
Alexander Morley (4487878) +23 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source