Results 101 to 110 of about 2,742,145 (306)
Open Source Software: From Open Science to New Marketing Models [PDF]
-Open source Software; Intellectual Property; Licensing; Business Model.
Paola Giuri +2 more
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Open Source Software: The New Intellectual Property Paradigm [PDF]
Open source methods for creating software rely on developers who voluntarily reveal code in the expectation that other developers will reciprocate. Open source incentives are distinct from earlier uses of intellectual property, leading to different types
Stephen M. Maurer, Suzanne Scotchmer
core
Modifying the universe around us: the design act as transformative semiosis process .
InmaterialUnderlying the anthropocosmic conception of the philosopher Valery Nikolaevich Sagatovsky is the understanding of being as a unitary totality in which matter, soul and spirit are on an equal footing in terms of dignity and value.
Tiziano Manna
doaj
Addressing infectious diseases in Africa by accelerating drug discovery through data science
Communications MedicineDespite being rich in natural resources and scientific talent, Africa continues to bear a staggering infectious disease burden. Historically, health innovation on the continent has relied on international funding and has been constrained by limited ...
Gemma Turon +4 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Open Source Software, Competition and Potential Entry [PDF]
We analyze a model with two software firms, quality improving coding expenditures and potential competition. The firms can publish parts of their software as open source.
Thorsten Wichmann, Pio Baake
core
Frontiers in MedicineThe National Academies of Science, Engineering, and Medicine (NASEM) has defined Long COVID as “an infection-associated chronic condition (IACC) that occurs after SARS-CoV-2 infection and is present for at least 3 months as a continuous, relapsing and ...
Matthew Halma +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source