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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Open Source in libraries [PDF]
Author presents his opinions about open source software, explains possible mistakes and obstacles as well as good sides of such a software.
Lease Morgan, Eric
core
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Imaging Multispettrale low-cost con filtri interferenziali
Multispectral imaging systems are used in art examination in order to map and identify pigments and binders as well as retouches. A monochromatic camera (CCD or InGaAs) is combined with an appropriate wavelength selection system, simple as a set of ...
Antonio Cosentino
doaj +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
What is the “Source” of Open Source Hardware?
What “open source” means once applied to tangible products has been so far mostly addressed through the light of licensing. While this approach is suitable for software, it appears to be over-simplistic for complex hardware products.
Jérémy Bonvoisin +3 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Layer-Wise Personalized Federated Learning for Mobile Traffic Prediction
With the evolution of mobile networks delivering high-performance network services to a myriad of devices, accurate mobile traffic prediction has become increasingly important.
Seungyeol Lee +2 more
doaj +1 more source
Support mechanisms provided by FLOSS foundations and other entities
Foundations function as a vital institutional support infrastructure for many of the most successful open-source projects, but the different roles played by these support entities are understudied in Free/Libre and Open Source Software (FLOSS) research ...
Juho Lindman, Imed Hammouda
doaj +1 more source
Open Source Business Solutions [PDF]
This analyses the Open source movement. Open source development process and management is seen different from the classical point of view. This focuses on characteristics and software market tendencies for the main Open source initiatives. It also points
Ion IVAN, Radu BUCEA-MANEA-TONIS
core

