Results 111 to 120 of about 1,565,431 (306)

Exploring the unknowns of international open innovation and international dynamic capabilities on the speed of innovation and firm international performance: A strategic view

Journal of Innovation & Knowledge
Technological advancements are forcing firms to innovate quickly to sustain a competitive advantage. However, despite theoretical arguments and empirical findings, the mechanisms that influence the speed of innovation and firms’ international performance
Noor Ul Hadi, Imtiaz Ali
doaj   +1 more source

Managing Search Strategies for Open Innovation: The Role of Environmental Munificence as well as Internal and External R&D [PDF]

Firms compete increasingly in an open innovation environment. Search strategies for external knowledge become therefore crucial for firm success. Existing research differentiates between the breadth (diversity) and depth (intensity) with which firms ...
Grimpe, Christoph, Sofka, Wolfgang
core  

Does open innovation foster productivity? Evidence from Open Source Software (OSS) firms [PDF]

, 2008
The primary findings of our study suggest that software firms that adopt the OSS-based business model are notably less productive than companies that merely offer proprietary software solutions.
Harison, Elad, Koski, Heli
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

Nature Communications
The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target.
Xiaomin Ni, R. Blake Richardson, Andre Schutzer Godoy, Matteo P. Ferla, Caroline Kikawa, Jenke Scheen, William W. Hannon, Eda Capkin, Noa Lahav, Blake H. Balcomb, Peter G. Marples, Michael Fairhead, SiYi Wang, Eleanor P. Williams, Charles W. E. Tomlinson, Jasmin C. Aschenbrenner, Ryan M. Lithgo, Max Winokan, Charline Giroud, Isabela Dolci, Rafaela Sachetto Fernandes, Glaucius Oliva, Anu V. Chandran, Mary-Ann Xavier, Martin A. Walsh, Warren Thompson, Jesse D. Bloom, Nathaniel T. Kenton, Alpha A. Lee, Annette von Delft, Haim Barr, Karla Kirkegaard, Lizbé Koekemoer, Daren Fearon, Matthew J. Evans, Frank von Delft   +35 more
doaj   +1 more source

Review of Open-Source AI Tools for Healthcare IT Infrastructures

IEEE Access
Open-source artificial intelligence (AI) in the healthcare sector has the potential to revolutionize the industry by improving accessibility, efficiency, and accuracy of medical services.
Younis Mohammed Al-Kharusi, Ajmal Khan, Muhammad Rizwan Mughal, Mohammed M. Bait-Suwailam   +3 more
doaj   +1 more source

Open Source Software, Closed Source Software or Both: Impacts on Industry Growth and the Role of Intellectual Property Rights [PDF]

There is considerable debate regarding the use of intellectual property rights (IPR) to spur innovation in the software industry. In this paper we focus on the choice of intellectual property right regimes and industry growth.
Sebastian von Engelhardt, Sushmita Swaminathan   +1 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Dynamics of Innovation in an “Open Source” Collaboration Environment: Lurking, Laboring and Launching FLOSS Projects on SourceForge [PDF]

A systems analysis perspective is adopted to examine the critical properties of the Free/Libre/Open Source Software (FLOSS) mode of innovation, as reflected on the SourceForge platform (SF.net).
Francesco Rullani, Paul David
core