Results 131 to 140 of about 1,565,431 (306)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Introducing innovations into Open Source projects

, 2011
Diese Dissertation widmet sich der Fragestellung, wie Technologien, Werkzeuge und Prozesse der Softwaretechnik in Open-Source-Projekte eingeführt werden können. Zur Beantwortung dieser Frage werden 13 mittelgroße Open-Source- Projekte mit Hilfe der Grounded Theory Methodology untersucht und die gewonnenen Erkenntnisse in acht Kernkategorien ...
openaire   +1 more source

Is open source software about innovation? Collaborations with the open source community and innovation performance of software entrepreneurial ventures

, 2012
Practitioners generally assert that collaborations with the open source software (OSS) community enable software entrepreneurial ventures to achieve superior innovation performance. Nonetheless, scholars have never tested this assertion. This paper takes a first step toward filling this gap. First, based on the high-tech entrepreneurship literature and
PIVA, EVILA, Rentocchini, Francesco, ROSSI, CRISTINA   +2 more
openaire   +5 more sources

Incentives for Developers’ Contributions and Product Performance Metrics in Open Source Development: An Empirical Exploration [PDF]

In open source software development, users rather than paid developers engage in innovation and development without the direct involvement of manufacturers.
Chakravarty Sujoy, Haruvy Ernan E, Wu Fang   +2 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The economic impact of open science: a scoping review

Royal Society Open Science
This article summarizes a comprehensive scoping review of the economic impact of open science (OS), examining empirical evidence from 2000 to 2023.
Lena Tsipouri, Sofia Liarti, Silvia Vignetti, Izabella Martins Grapengiesser   +3 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CRITICAL SUCCESS FACTORS FOR OPEN-SOURCE INNOVATION: THE CASE OF OPEN SOURCE SOFTWARE DEVELOPMENT [PDF]

Issues in Information Systems, 2009
Gang Peng
doaj