Results 51 to 60 of about 3,361,942 (285)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analisa Tingkat Usability Software Open Source ICA-AtoM
Khazanah: Jurnal Pengembangan Kearsipan, 2017 Penelitian ini membahas dan mengkaji mengenai seberapa tingkat usability salah satu software bidang arsip digital dengan berbasis opensource yaitu ICA-AtoM. Latar belakang penulisan adalah dengan perkembangan teknologi informasi yang sudah menjadi bagian
Ach. Nizam Rifqi
doaj +1 more source
Open Geospatial Software and Data: A Review of the Current State and A Perspective into the Future
ISPRS International Journal of Geo-Information, 2020 All over the world, organizations are increasingly considering the adoption of open source software and open data. In the geospatial domain, this is no different, and the last few decades have seen significant advances in this regard.
Serena Coetzee +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Data Mining Techniques for Software Quality Prediction in Open Source Software [PDF]
EPJ Web of Conferences, 2019 Software quality monitoring and analysis are among the most productive topics in software engineering research. Their results may be effectively employed by engineers during software development life cycle.
Canaparo Marco, Ronchieri Elisabetta
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The Free Software Alternative: Freeware, Open Source Software, and Libraries
Information Technology and Libraries, 2014 : This paper will introduce the reader to the world of freeware and open source software. Following a brief introduction, the author presents an overview of these types of software.
James Edward Corbly
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Patching It Up, Pulling It Forward
Journal of Open Research Software, 2015 An important reason for making any software open source is to encourage code and other community contributions, resulting in more diverse developer communities coalescing around valuable software efforts.
Marlon E. Pierce +2 more
doaj +1 more source