Results 81 to 90 of about 3,031,803 (287)

Software architectures and Open Source Software: Where can research leverage the most? [PDF]

, 2001
Software architectures have been playing a central role in software engineering research for some years now. They are considered of pivotal importance in the success of complex software systems development.
Arief, B., Gacek, C., Lawrie, T.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Network Perimeter Defenses Using Open-Source Software

Iraqi Journal of Information & Communication Technology, 2018
network security role grew exponentially in the late several years, especially with the notable amount of attacks that target all types of organizations and services.
Mohammed A. Al-Qassim, Emad H. Al-Hemiary   +1 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Automating Open Source Software License Information Generation in Software Projects [PDF]

Journal of Systemics, Cybernetics and Informatics, 2018
This publication deals with Open Source Software (OSS) compliance. In a previous publication [1], we presented an organizational-technical concept for ensuring basic OSS compliance. Based on this concept, we now address further aspects that are essential
Sergius Dyck, Daniel Haferkorn, Christian Kerth, André Schoebel   +3 more
doaj  

Open Source Software, Competition and Potential Entry [PDF]

We analyze a model with two software firms, quality improving coding expenditures and potential competition. The firms can publish parts of their software as open source.
Pio Baake, Thorsten Wichmann
core  

Impact assessment for vulnerabilities in open-source software libraries

, 2015
Software applications integrate more and more open-source software (OSS) to benefit from code reuse. As a drawback, each vulnerability discovered in bundled OSS potentially affects the application.
Plate, Henrik, Ponta, Serena Elisa, Sabetta, Antonino   +2 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Open source software development: some historical perspectives [PDF]

software development ...
Nuvolari, A.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source