Results 51 to 60 of about 2,887,710 (306)

Improving operating room safety [PDF]

, 2009
Despite the introduction of the Universal Protocol, patient safety in surgery remains a daily challenge in the operating room. This present study describes one community health system's efforts to improve operating room safety through human factors ...
Hurlbert Scott N, Scott N Hurlbert, Garrett Jill, Jill Garrett, Scott N Hurlbert   +4 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Comprehensive perioperative management of a giant neurofibroma complicated by hemorrhagic shock: a case report

Frontiers in Surgery
Giant neurofibromas are rare benign peripheral nerve sheath tumors, most often occurring in association with neurofibromatosis type I. Tumor rupture may be followed by massive bleeding and hemorrhagic shock, posing life-threatening challenges during ...
Jiye Sang, Guojun Zhao, Yanhong Zhang, Liming Sun, Mingming Zhao, Mingming Zhao   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Nurse-led discharge versus consulting surgeon-led discharge for patients who underwent laparoscopic surgeries: an evaluation of follow-up outcome, readmission frequencies, cost of care, and satisfaction of patients

BMC Nursing
Background Consulting surgeons review admitted patients and make decisions regarding their fitness for discharge. This leads to a delay in discharge. Delayed hospital discharge is an issue faced by patients after laparoscopic surgery, which increases ...
Bing Yang, Xiaotang Luo, Peiwei Wang, Pengfei Pan, Peishan Lin, Wenjie Zhao   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Current status and factors associated with sexual harassment among operating room nurses: a multi-center cross-sectional study

BMC Nursing
Aims The purpose of this study was to investigate the prevalence of sexual harassment among operating room nurses, and to analyze the influencing factors.
Lingyu Tang, Xingli Yu, Yanshu Liu, Jie Zhou, Daiying Zhang, Juan Wang, Qingyan Liu   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Perioperative nurses’ perceptions of competence: Implications for migration

, 2012
Background. Nurses' recognition of their own level of skills and abilities (ie perceived competence) is a prerequisite for ensuring they can practice in a safe manner.
Gillespie, Brigid, Lingard, Shirley, Ball, Sharon, Chaboyer, Wendy   +3 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source