Results 231 to 240 of about 3,338,059 (292)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sleep Health and Obstructive Sleep Apnea Risk in Portuguese Firefighters: Preliminary Baseline Findings From a Prospective Cohort. [PDF]

Cureus
Da Silva Alves C, Caldeira L, Ribeiro P, Osório A, Longo P, Dâmaso P, Macedo A, Lopes L, Longo C.   +8 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A direct qualitative content analysis on the design, implementation, and evaluation of prehospital earthquake exercises aligned with the HSEEP framework. [PDF]

Int J Emerg Med
Aminafshar A, Chaleshtori AM, Khosravizad A, Sahebi A, Farahmandnia H.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Operational efficiencies of using one vs multiple bispecific antibodies for diffuse large B-cell lymphoma and follicular lymphoma in the US. [PDF]

Future Oncol
Graff T, Bains Chawla S, Jun M, Heaps N, Alshreef A, Tybor D, Moore DC, Zawadzki N, Spurrier K, Shafrin J.   +9 more
europepmc   +1 more source

Stakeholder Perspectives on Affinity Domains in Digital Health Interoperability: Qualitative Study.

JMIR Med Inform
Bruthans J, Hospodková P, Fejfarová I.
europepmc   +1 more source

LINA's testing infrastructure enables AI to take-off in unmanned aerial vehicles (UAVs). [PDF]

Front Robot AI
Bolck HA, Vollenweider J, Merkli F, Barden A, Jajcay M, Trempeck P, Rafailović B, Fraefel R, Lenhart PM, Chavarriaga R, Renold M, Bogojeska J, Stadelmann T, Guillaume M.   +13 more
europepmc   +1 more source

Institutional Biobanking as shared public health infrastructure: a financially sustainable service center model. [PDF]

Front Health Serv
Olson MV.
europepmc   +1 more source