Results 141 to 150 of about 97,874 (341)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Immunity of Operational Amplifiers against High Frequency and High Amplitude Pulse Interferences
, 2014 Osunde O.D, Anyaoha S.N.
openalex +1 more source
Processing of Communication Signal Using Operational Transconductance Amplifier [PDF]
, 2010 Arabinda Roy +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
IDDQ Testing of Low Voltage CMOS Operational Transconductance Amplifier
, 2018 Maninder Kaur, Jasdeep Kaur
openalex +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
High Pass Filter and Bandpass Filter Using Current Feedback Operational Amplifier (CFOA) [PDF]
, 2018 Ridouane Hamdaouy
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
CMOS Current Feedback Operational Amplifier-Based Relaxation Generator for Capacity to Voltage Sensor Interface. [PDF]
Sensors (Basel), 2018 Polak L +3 more
europepmc +1 more source