Results 81 to 90 of about 63,196 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Inequalities connected with averaging operators. Part II

Indagationes Mathematicae, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Unbounded products of operators and connections to Dirac-type operators

Bulletin des Sciences Mathématiques, 2014
Let $A$ and $B$ be two densely defined unbounded closeable operators in a Hilbert space such that their unbounded operator products $AB$ and $BA$ are also densely defined. Then all four operators possess adjoints and we obtain new inclusion bounds for the operator product closures $\bar{A} \bar{B}$ and $\bar{AB}$ in terms of new relations among the ...
Gustafson, Karl, Mortad, Mohammed Hichem
openaire   +2 more sources

A Proposed Lean Approach Model to Increase the Operational Efficiency of Natural Gas Connection Installations in Metropolitan Lima [PDF]

, 2023
Juan Carlos Quiroz-Flores, Carlos Cepeda-Zavala, Estefanie Terry-Alba, S. Nallusamy   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Hybrid Systems of Distributed Generation with Renewable Sources: Modeling and Analysis of Their Operational Modes in Electric Power System

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2013
The paper considers problems pertaining to modeling and simulation of operational hybrid system modes of the distributed generation comprising conventional sources – modular diesel generators, gas-turbine power units; and renewable sources – wind and ...
A. M. Gashimov, N. R. Rakhmanov, S. T. Akhmedova   +2 more
doaj  

Transport accessibility changes in metropolitan regions: high-speed rail connection frequency estimation

European Spatial Research and Policy
This article focuses on a very narrowly specific segment of this issue, considering the impacts of HSR in the long term, not as transport arteries connecting the most important metropolitan areas but, on the contrary, as an internal factor of development
Martin Vrána, Petr Hlisnikovský, Vilém Pařil, Simona Surmařová, Jan Ilík   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Study on the correlation between the hierarchical urban system and high-speed railway network planning in China

Frontiers of Architectural Research, 2016
This study examines the interrelatedness between the hierarchical structure of China׳s urban system and high-speed railway (HSR) network planning at the national level. As a multi-layered system, the Chinese HSR can be categorized into three sub-networks,
Hong Sun
doaj   +1 more source

Characterizations of operations derived from network connections

Journal of Mathematical Analysis and Applications, 1976
Through study of electrical network connections, Anderson and Duffin [2] introduced the concept of parallel sum of two Hermitian semidefinite matrices, and subsequently Anderson [l] defined a matrix operation, called shorted operation to a subspace, for each Hermitian semidefinite matrix.
Nishio, Katsuyoshi, Ando, Tsuyoshi
openaire   +2 more sources