Results 101 to 110 of about 2,204,053 (310)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Managing Operational Risk in Payment, Clearing, and Settlement Systems [PDF]
Awareness of operational risk has increased greatly in recent years, both at individual financial institutions and for payment, clearing, and settlement systems (PCSS).
Kim McPhail
core
Operational modal analysis of low frequency surface waves in Lakes and reservoirs
, 2019 Wind driven oscillations of water surfaces (surface seiches) are a key driver of ecological fluxes, such as of oxygen and nutrients, within lakes and reservoirs.
Bouffard, Damien (author) +4 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
European Spatial Research and PolicyThis article focuses on a very narrowly specific segment of this issue, considering the impacts of HSR in the long term, not as transport arteries connecting the most important metropolitan areas but, on the contrary, as an internal factor of development
Martin Vrána +4 more
doaj +1 more source
Research of the Power Plant Operational Modes
MATEC Web of Conferences, 2017 In this article the algorithm of the power plant operational modes research is offered. According to this algorithm the program for the modes analysis and connection power transformers choice is developed. The program can be used as educational means for
Koismynina Nina M., Valiev Timur T.
doaj +1 more source
The natural operators of general affine connections into general affine connections
Annales Universitatis Mariae Curie-Sklodowska, sectio A – Mathematica, 2017 We reduce the problem of describing all \(\mathcal{M} f_m\)-natural operators transforming general affine connections on \(m\)-manifolds into general affine ones to the known description of all \(GL(\mathbf{R}^m)\)-invariant maps \(\mathbf{R}^{m*}\otimes \mathbf{R}^m\to \otimes^k\mathbf{R}^{m*}\otimes\otimes ^k\mathbf{R}^m\) for \(k=1,3\).
Kurek, Jan, Mikulski, Włodzimierz M.
openaire +3 more sources
Leveraging the Operational Excellence Platform for Improvement: Strengthening Culture of Safety [PDF]
, 2023 Senior leaders drive the culture change by demonstrating their own commitment to safety and providing the resources to achieve results. Their consistent and sustained messages about safety help advance a culture of safety 1.
Nayak, Suneela +3 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source