Results 131 to 140 of about 10,006,314 (254)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

HFM 128/143: Moderators as a Method to Link HF to Operational Behaviour

open access: yes, 2010
In an attempt to define a generic way to include human factors in a simulation of military operations HFM 128 suggested to break the causal chain between human factors as input and operational outcome into three components: a) human factors science based
Lotens, W.   +7 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A strategic model of operational performance improvement [PDF]

open access: yes
Performance improvement is the natural objective of any intervention in the organisation. Performance improvement in operational terms is particularly interesting when it is able to influence the competitive position of the firm.
Alher, Fabio
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Operational Excellence and Sustainable Business Performance: Operational Performance Mediation in Indonesian Manufacturing Firms

open access: yes
Sustainable business performance has become a strategic priority for manufacturing firms as increasing environmental regulations and competitive pressures require organizations to integrate operational efficiency with sustainability objectives.
Yoki Muchsam   +2 more
core   +1 more source

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