Results 51 to 60 of about 494,728 (259)
BMC Public HealthBackground Female sex workers (FSWs) face elevated risks of both HIV acquisition and unintended pregnancies. While oral pre-exposure prophylaxis (PrEP) is an established HIV prevention tool, its broader impact on sexual and reproductive health (SRH ...
Jean-Pierre Yves Awono Noah +8 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Scientific ReportsTuberculosis, a deadly and contagious disease caused by Mycobacterium tuberculosis, remains a significant global public health threat. HIV co-infection significantly increases the risk of active TB recurrence and prolongs medical treatment for ...
Declan I. Emegano +5 more
doaj +1 more source
Localised transmission hotspots of a typhoid fever outbreak in the Democratic Republic of Congo
The Pan African Medical Journal, 2017 INTRODUCTION: In a semi-urban setting in the Democratic Republic of Congo, this study aims to understand the dynamic of a typhoid fever (TF) outbreak and to assess: a) the existence of hot spots for TF transmission and b) the difference between typhoid ...
Engy Ali +9 more
doaj +1 more source
Navy Operations Research [PDF]
Operations Research, 2002 This paper emphasizes OR's utility to the U.S. Navy, as seen by its customers. Like many naval officers who subspecialized in operations research, the author was both producer and consumer of analysis toward improving fleet operations, Pentagon planning, and training effectiveness.
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source