Results 131 to 140 of about 312,703 (305)

New Trends regarding the Operational Risks in Financial Sector [PDF]

Risks, especially "operational risks" are part of corporate life, they are the essence of financial institutions' activities. Operational risks are complex and often interlinked and have to be managed properly.
Laura Giurca Vasilescu
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Operational risk escalation: An empirical analysis of UK call centres

, 2013
The paper investigates operational risk reporting behaviour and policy dissemination in the selling of financial products by a major British insurance company's call centres.
Webb, Rob, Cheevers, Carly, Bryce, Cormac   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Riesgo operacional: reto actual de las entidades financieras

Revista Ingenierías Universidad de Medellín, 2006
El presente artículo es uno de los resultados de un proyecto de investigación sobre gestión integral del riesgo operacional, promovido por la Vicerrectoría de Investigaciones de la Universidad de Medellín.
Juan Camilo Arbeláez, Luis Ceferino Franco, César Betancur, Juan Guillermo Murillo, Paula Andrea Gallego, Viviana María Henao, Johana Andrea Londoño, Claudia Marcela Mejía, Diana Marcela Palacio, Elizabeth Salazar, Luisa Fernanda Salazar, Natalia Valderrama, Diana Carolina Varela   +12 more
doaj  

Assessment of Operational Risk based on Copula Approach

Solvency II Directive requirements should establish common risk management principles for every insurance company in the European Union. Basically, the requirements of the Solvency II Directive are not just about capital of an insurance company but about
Voronova, Irina, Stepčenko, Darja
core  

An alternative approach for the operational risk assessment of a new product

, 2019
The risk assessment of a new product is one of the most critical activities performed by the operational risk management of a company operating in the financial sector.
Moretti, Jacopo, Cesarone, Francesco, Jacopo Moretti, Fabio Tardella, Giacchero, Andrea, Tardella, Fabio, Francesco Cesarone, Andrea Giacchero   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source