Results 101 to 110 of about 2,626,282 (391)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Surgical treatment and outcome of spinal arteriovenous malformations

Medicinski Glasnik
Aim A rare and diverse set of abnormalities formed by spinal blood arteries known as spinal arteriovenous malformations (AVMs) has a higher risk of haemorrhage and morbidity, causing the shunting of blood from veins with an aberrant capillary bed to ...
Andhika Yudistira, Syaifullah Asmiragani, Ery Satriawan Muammar   +2 more
doaj   +1 more source

Influência do trauma cirúrgico no comportamento dos níveis séricos de albumina após cirurgia da coluna vertebral Influencia del trauma quirúrgico sobre el comportamiento de los niveles de albúmina sérica después de cirugía de columna vertebral Influence of surgical trauma on the behavior of serum albumin after spine surgery

Coluna/Columna, 2010
OBJETIVO: avaliar a variação da concentração da albumina nas cirurgias de coluna vertebral e relacioná-la às repercussões clínicas no pós-operatório. MÉTODOS: estudo prospectivo observacional sobre os valores do nível sérico da albumina de 55 pacientes ...
Rafael Paiva Luciano, Marcio Squassoni Leite, Délio Eulálio Martins, Marcelo Wajchenberg, Eduardo Barros Puertas   +4 more
doaj   +1 more source

Case studies in rural co-operatives: three studies of the organisation and management or rural co-operatives providing post-harvest facilities in the kiwifruit industry: a research report submitted in partial fulfilment of the requirements for the degree of Master of Agricultural Business and Administration at Massey University [PDF]

, 1983
The co-operative ownership structure is one that is commonly encountered in New Zealand's agricultural industry. This type of organisation would appear to have a number of natural advantages that should make it very competitive in modern agri-business ...
Beattie, Michael Ian
core  

Adrenal Cysts: To Operate or Not to Operate?

Journal of Clinical Medicine
Adrenal cysts are uncommon and usually asymptomatic, and therefore are usually incidentally discovered adrenal lesions. They have a broad pathohistological spectrum that includes pseudocysts and endothelial (vascular), parasitic, and epithelial (mesothelial) cysts.
Ivana Bozic Antic, Igor Djurisic, Srdjan Nikolic   +2 more
openaire   +3 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications

Frontiers in Surgery
IntroductionSpinal tuberculosis (TB), or Pott's disease, remains a significant global health issue, particularly in regions with high TB prevalence. Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required ...
Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono   +7 more
doaj   +1 more source

To Operate or not to Operate? That is the question

Journal of ISAKOS, 2018
Anterior cruciate ligament (ACL) injuries amongst children worry us more than other age groups. An ACL rupture can limit a child’s present physical activity and contentment. But it can also threaten his or her adulthood, with an increased risk of further injury, leading to meniscal tears and early osteoarthritis.
openaire   +2 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source