Results 91 to 100 of about 733,074 (265)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Optimal management of thumb basal joint arthritis: challenges and solutions

Orthopedic Research and Reviews, 2017
Christopher Higgenbotham,1 Alan Boyd,1 Michelle Busch,1 Dennis Heaton,2 Thomas Trumble1 1Hand Institute, Bellevue Bone and Joint Physicians, Bellevue, School of Medicine, 2Pacific Northwest University, Yakima, WA, USA Abstract: Up to 15% of the ...
Higginbotham C, Boyd A, Busch M, Heaton D, Trumble T   +4 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Natural history and surgical treatment of chordoma: a retrospective cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Chordoma is a rare tumor with a high risk of locoregional recurrences. The aim of this study was analyze the long-term results from treating this pathological condition.DESIGN AND SETTING: Cohort study in a single hospital in São ...
Samuel Aguiar Júnior, Wesley Pereira Andrade, Glauco Baiocchi, Gustavo Cardoso Guimarães, Isabela Werneck Cunha, Daniel Alvarez Estrada, Sergio Hideki Suzuki, Luiz Paulo Kowalski, Ademar Lopes   +8 more
doaj   +1 more source

On second order operators and quadratic operators

2008 19th International Conference on Pattern Recognition, 2008
In pattern recognition, computer vision, and image processing, many approaches are based on second order operators. Well-known examples are second order networks, the 3D structure tensor for motion estimation, and the Harris corner detector. A subset of second order operators are quadratic operators.
openaire   +3 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The $$\circ$$ Operation and $$*$$ Operation of Fan Graphs

Mathematical Notes
Let $G$ be a finite simple graph on the vertex set $V$ and let $I_G$ denote its edge ideal in the polynomial ring $S=\mathbb{K}[x_V]$. In this paper, we compute the depth and the Castelnuovo--Mumford regularity of $S/I_G$ when $G=F_{k}^{W}(K_n)$ is a $k$-fan graph, or $G=G_1\circ G_2$ or $G=G_1* G_2$ is the graph obtained from fan graphs $G_1$, $G_2 ...
Zhu, G., Cui, Y., Yang, Y., Yang, Y.
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source