Results 101 to 110 of about 1,157,536 (288)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Estudo comparativo de retalhos tubulares de pele de ratos com dois tipos de cateter como molde

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: A tubulização de retalhos de pele é um artifício técnico muito empregado na correção de hipospádias. Existem controvérsias quanto aos riscos e benefícios do uso de sondas para moldar a neo-uretra e promover a derivação urinária.
Antonio Henrique Rodrigues dos Passos, Fernando Costa, Lúcio Tedesco Marchese   +2 more
doaj   +1 more source

Modification of the gasless fetoscopy technique for the treatment of large myelomeningocele: a study in sheep [PDF]

Einstein (São Paulo), 2010
Objective: To change the gasless fetoscopy technique in order to reduce the diameter of entry orifices in the myometrium. Methods: Seven pregnant ewes were submitted to fetoscopy for repairing a large skin defect measuring 4.0 x 3.0 cm, created in the ...
Denise Araujo Lapa Pedreira, Gregório Lorenzo Acácio, Rogério Chaccur Abou-Jamra, Rita de Cássia Sanches Oliveira, Elia Garcia Caldini, Paulo Hilário Nascimento Saldiva   +5 more
doaj  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Optimal management of thumb basal joint arthritis: challenges and solutions

Orthopedic Research and Reviews, 2017
Christopher Higgenbotham,1 Alan Boyd,1 Michelle Busch,1 Dennis Heaton,2 Thomas Trumble1 1Hand Institute, Bellevue Bone and Joint Physicians, Bellevue, School of Medicine, 2Pacific Northwest University, Yakima, WA, USA Abstract: Up to 15% of the ...
Higginbotham C, Boyd A, Busch M, Heaton D, Trumble T   +4 more
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Natural history and surgical treatment of chordoma: a retrospective cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Chordoma is a rare tumor with a high risk of locoregional recurrences. The aim of this study was analyze the long-term results from treating this pathological condition.DESIGN AND SETTING: Cohort study in a single hospital in São ...
Samuel Aguiar Júnior, Wesley Pereira Andrade, Glauco Baiocchi, Gustavo Cardoso Guimarães, Isabela Werneck Cunha, Daniel Alvarez Estrada, Sergio Hideki Suzuki, Luiz Paulo Kowalski, Ademar Lopes   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source