Results 91 to 100 of about 1,139,169 (382)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Comparison of osseointegration in piezoimplants versus cylindrical implants [PDF]

open access: yes, 2019
BACKGROUND: Dental implants have been successful for the restoration of edentulous areas, but current techniques are inadequate in areas lacking sufficient bone volume. Piezoelectric surgery has shown encouraging effects on both osseous healing.
Fujinaka, Trevor
core  

A procedure for implanting a spinal chamber for longitudinal in vivo imaging of the mouse spinal cord. [PDF]

open access: yes, 2014
Studies in the mammalian neocortex have enabled unprecedented resolution of cortical structure, activity, and response to neurodegenerative insults by repeated, time-lapse in vivo imaging in live rodents.
Farrar, Matthew J, Schaffer, Chris B
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Prophylactic antibiotic regimens in tumour surgery (PARITY): a pilot multicentre randomised controlled trial. [PDF]

open access: yes, 2015
ObjectiveClinical studies of patients with bone sarcomas have been challenged by insufficient numbers at individual centres to draw valid conclusions.
PARITY Investigators
core   +1 more source

Surgical management of the cases with both biliary and duodenal obstruction

open access: yesGastrointestinal Intervention, 2018
Endoscopic management is presently the recommended first-line of treatment for biliary strictures. However, surgery still has an important role especially for biliary obstruction (BO) with duodenal obstruction.
Yoshihiro Miyasaka   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Paratesticular leiomyosarcoma treated by enucleation

open access: yesInternational Brazilian Journal of Urology, 2006
Spermatic cord leiomyosarcomas are rare tumors and standard treatment consists of radical orchiectomy and high cord ligation. We report a case of a paratesticular leiomyosarcoma successfully treated by enucleation.
Roberto I. Lopes   +2 more
doaj   +1 more source

Post-Operative Vision Loss (POVL) following Surgical Procedures

open access: yesJournal of Anesthesia & Clinical Research, 2012
Backgound: Postoperative vision loss (POVL), with a prevalence of 0.1% of cardiopulmonary bypass cases and 0.02% - 0.2% of spine surgery cases, is a rare but devastating complication that can occur in patients undergoing surgery in the prone position.
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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