Results 111 to 120 of about 448,965 (315)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
International Journal of Women's HealthMiao Liang,* Yu Wen,* Yongkang Li, Xiaofan Zhu, Cheng Chen Department of Gynaecology and Obstetrics, Chongqing General Hospital, Chongqing University, Chongqing, 401147, People’s Republic of China*These authors contributed equally
Liang M, Wen Y, Li Y, Zhu X, Chen C
doaj
Revista do Colégio Brasileiro de CirurgiõesObjective: to analyse the indications and results of the total esophagogastrectomy in cancers of the distal esophagus and esophagogastric junction. Methods: twenty patients with adenocarcinomas were operated with a mean age of 55 ± 9.9 years (31-70 ...
Nelson Adami Andreollo +4 more
doaj +1 more source
Surgical treatment of gastric cancer: a 10-year experience in a high-volume university hospital
Clinics, 2018 OBJECTIVES: Surgery remains the cornerstone treatment modality for gastric cancer, the fifth most common type of tumor in Brazil. The aim of this study was to analyze the surgical treatment outcomes of patients with gastric cancer who were referred to a ...
Marcus Fernando Kodama Pertille Ramos +9 more
doaj +1 more source
Guidance for delivering surgical procedures outside operating theatres: scoping review
BJS OpenAbstract Background This review aimed to examine in-depth the extent and content of guidance related to the delivery of surgical procedures outside of the operating theatre. Methods Documents concerning the delivery of surgical ...
Osborne-Grinter, M +7 more
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Surgical Release of Dupuytren's Contracture Using Multiple Transverse Incisions
Archives of Plastic Surgery, 2012 Dupuytren's contracture is a condition commonly encountered by hand surgeons, although it is rare in the Asian population. Various surgical procedures for Dupuytren's contracture have been reported, and the outcomes vary according to the treatment ...
Hyunjic Lee +3 more
doaj +1 more source
A standardized comparison of peri-operative complications after minimally invasive esophagectomy: Ivor Lewis versus McKeown. [PDF]
, 2018 BACKGROUND: While our institutional approach to esophageal resection for cancer has traditionally favored a minimally invasive (MI) 3-hole, McKeown esophagectomy (MIE 3-hole) during the last five years several factors has determined a shift in our ...
Berger, Adam C. +6 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source