Results 121 to 130 of about 293,996 (313)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Abdominal integument atrophy after operative procedures

, 2012
The aim of the study was to analyze clinical material concerning postoperative atro‑ phy of abdominal integument. Material and methods: The evaluated group consisted of 29 patients with sonographically revealed atrophy of the abdominal wall.
Elżbieta Bernatowicz, Maria Gałdyńska, Katarzyna Kołaczyk, Stefania Bojko, Kołaczyk, Katarzyna, Gałdyńska, Maria, Bojko, Stefan, Smereczyński, Andrzej, Jan Lubiński, Bernatowicz, Elżbieta, Andrzej Smereczyński, Lubiński, Jan   +11 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The risk of post-operative complications in psoriasis and psoriatic arthritis patients on biologic therapy undergoing surgical procedures.

, 2015
BACKGROUND: There is limited evidence as to whether biologic therapy should be stopped or continued in patients with psoriasis and/or psoriatic arthritis (PsA) who are undergoing surgical procedures.
Bakkour, W, Chinoy, Hector; id_orcid, Griffiths, CEM, Warren, RB, Purssell, H   +4 more
core   +1 more source

Novel penile circumcision suturing devices versus the shang ring for adult male circumcision: a prospective study

International Brazilian Journal of Urology
Introduction To evaluate the safety and efficacy of a novel penile circumcision suturing devices PCSD and Shang ring (SR) for circumcision in an adult population. Materials and Methods A total of 124 outpatients were randomly assigned to receive PCSD (
Hu Han, Da-wei Xie, Xiao-guang Zhou, Xiao-dong Zhang   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Dehiscence of a Composite Aortic Graft and Pseudoan- eursym Late After a Bentall Operation

Journal of Tehran University Heart Center, 2015
A 32-year-old female patient with previous Bentall operation and mitral valve repair surgery due to severe aortic insufficiency, mitral valve insufficiency, and ascending aortic aneurysm was admitted to our hospital with serious dyspnea, fatigue, and ...
Hasan Alper-Gurbuz, Ahmet Baris-Durukan, Cem Yorgancioglu   +2 more
doaj  

Urethral duplication type influences on the complications rate and number of surgical procedures

International Brazilian Journal of Urology
Introduction: Urethral duplication is rare. Characterized by the presence of two urethral channels. This anomaly presents a great variety of clinical findings that depend on the type of duplication that often is associated with other anomalies. Material
Roberto Iglesias Lopes, Amilcar Martins Giron, Marcos Figueiredo Mello, Cristovao Machado Barbosa Neto, Joana dos Santos, Paulo Renato Marcelo Moscardi, Victor Srougi, Francisco Tibor Denes, Miguel Srougi   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Safe surgery checklist: evaluation in a neotropical region

Revista do Colégio Brasileiro de Cirurgiões
Objective: assess patient responses and associated factors of items on a safe surgery checklist, and identify use before and after protocol implementation from the records.
GIULENA ROSA LEITE, MARLENE ANDRADE MARTINS, LUDMILA GREGO MAIA, MARCO TÚLIO ANTONIO GARCIA-ZAPATA   +3 more
doaj   +2 more sources