Results 101 to 110 of about 3,095,543 (301)

Transperitoneal laparoscopic pyeloplasty in children: does upper urinary tract anomalies affect surgical outcomes?

International Brazilian Journal of Urology
Objective To assess the feasibility and outcomes of laparoscopic pyeloplasty in children with complex ureteropelvic junction obstruction (UPJO) and compare to children with iso-lated UPJO without associated urinary tract abnormalities.
João Arthur Brunhara, Paulo Renato Marcelo Moscardi, Marcos Figueiredo Mello, Hiury Silva Andrade, Paulo Afonso de Carvalho, Bruno Nicolino Cezarino, Francisco Tibor Dénes, Roberto Iglesias Lopes   +7 more
doaj   +1 more source

Single scrotal incision orchiopexy - a systematic review

International Brazilian Journal of Urology, 2013
Objective To conduct a systematic review on single scrotal incision orchiopexy. Materials and Methods A search was performed using Pubmed, through which 16 articles were selected out of a total of 133.
Hugo Fabiano Fernandes Novaes, Jose Abraao Carneiro Neto, Antonio Macedo Jr, Ubirajara Barroso Junior   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Total esophagogastrectomy in the neoplasms of the esophagus and esofagogastric junction: when must be indicated?

Revista do Colégio Brasileiro de Cirurgiões
Objective: to analyse the indications and results of the total esophagogastrectomy in cancers of the distal esophagus and esophagogastric junction. Methods: twenty patients with adenocarcinomas were operated with a mean age of 55 ± 9.9 years (31-70 ...
Nelson Adami Andreollo, João de Souza Coelho Neto, Guilherme Delfino Calomeni, Luiz Roberto Lopes, Valdir Tercioti Junior   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Safe surgery checklist: evaluation in a neotropical region

Revista do Colégio Brasileiro de Cirurgiões
Objective: assess patient responses and associated factors of items on a safe surgery checklist, and identify use before and after protocol implementation from the records.
GIULENA ROSA LEITE, MARLENE ANDRADE MARTINS, LUDMILA GREGO MAIA, MARCO TÚLIO ANTONIO GARCIA-ZAPATA   +3 more
doaj   +2 more sources

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

CUMULATIVE INCIDENCE AND FACTORS ASSOCIATED WITH SURGICAL SITE INFECTIONS IN A HOSPITAL COHORT (2011–2025)

Brazilian Journal of Infectious Diseases
Introduction/Objective: Surgical site infections (SSIs) are a relevant complication, with potential negative impacts on patient recovery and hospital costs. Their occurrence may be influenced by patient-related factors, the contamination potential of the
Gabriela Nagem de Aragão, Lafaiete Barboza da Cruz, Nayane Beatriz Machado Silva, Carlos Magno Castelo Branco Fortaleza, Gabriel Berg de Almeida   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source