Results 101 to 110 of about 886,734 (291)
Esej poświęcony twórczości światowej sławy operatora Vittorio Storaro. Chmielecki analizuje wizualny aspekt Tanga Carlosa Saury. Autor argumentuje, że Storaro reprezentuje postawę, zgodnie z którą rzeczywistość profilmowa okazuje się zbyt uboga, by mogła
Konrad Chmielecki
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
JayaX: Jaya algorithm with xor operator for binary optimization
Jaya is a population-based heuristic optimization algorithm proposed for solving constrained and unconstrained optimization problems. The peculiar distinct feature of Jaya from the other population-based algorithms is that it updates the positions of ...
Aslan, Murat +2 more
core +1 more source
A relation between two simple Hardy-Mulholland-type inequalities with parameters
By means of weight coefficients and the technique of real analysis, a new Hardy-Mulholland-type inequality with the kernel K λ ( m , n ) : = 1 ln λ U m + ln λ V n + α | ln λ U m − ln λ V n | $$ K_{\lambda}(m,n):=\frac{1}{\ln^{\lambda}U_{m}+\ln^{\lambda ...
Qiang Chen, Yanping Shi, Bicheng Yang
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Fourier integrals and a new representation of Maslov's canonical operator near caustics [PDF]
We suggest a new representation of Maslov's canonical operator in a neighborhood of the caustics using a special class of coordinate systems (\eikonal coordinates") on Lagrangian ...
Dobrokhotov, Sergey +2 more
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