Results 81 to 90 of about 422,561 (267)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Operation Leyte – operational fires
Security and Defence Quarterly, 2018 <i>Operational fires are one of most important functions in a synergy effect with other operational functions that contribute to the achievement of targeted operational goals. The main operational goal of the American takeover of the Philippines was cutting Japan’s supply lines.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Information: Concept Clarification and Theoretical Representation
tripleC: Communication, Capitalism & Critique, 2011 The general theory of information is a synthetic approach, which organizes and encompasses all main directions in information theory. It is developed on three levels: conceptual, methodological and theoretical.
Mark Burgin
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Design of the strategy and architecture of different enterprises’ middle platform
Dianxin kexue, 2020 With the national economic transition and rapid development of technology,enterprises need digital transition.How to accelerate transition through IT architecture upgrading has become a new research topic for enterprises.The definition,function and ...
Yinghui LIU +4 more
doaj
On the existence and uniqueness of solution to Volterra equation on a time scale
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019 Using a global inversion theorem we investigate properties of the following ...
Kluczyński Bartłomiej
doaj +1 more source