Results 191 to 200 of about 273,383 (309)

Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro

open access: yesAdvanced Biology, EarlyView.
Non‐small cell lung cancer cells (A549) treated with a differentiation medium showed strong reduction in proliferation, migration, clonogenicity, spheroid formation and stemness markers, with enhanced adhesion properties and alveolar features, all pointing to a notably less aggressive phenotype in support of differentiation therapy as a promising ...
Alice Grossi   +10 more
wiley   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

open access: yesAdvanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen   +5 more
wiley   +1 more source

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

open access: yesAdvanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello   +5 more
wiley   +1 more source

Fabrication‐Directed Entanglement for Designing Chiral and Anisotropic Metamaterial Foams

open access: yesAdvanced Engineering Materials, EarlyView.
This work introduces fabrication‐directed entanglement (FDE), combining viscous thread printing and topology optimization to program entangled foams with spatially patterned stiffness. By tuning coil density, FDE enables anisotropy, programmable Poisson's ratio, and chirality in foams.
Daniel Revier   +3 more
wiley   +1 more source

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