Results 111 to 120 of about 3,849,527 (290)

The induced 2-tuple linguistic generalized OWA operator and its application in linguistic decision making [PDF]

We present the induced 2-tuple linguistic generalized ordered weighted averaging (2-TILGOWA) operator. This new aggregation operator extends previous approaches by using generalized means, order-inducing variables in the reordering of the arguments and ...
Jose M. Merigo Lindahl, Anna M. Gil-Lafuente   +1 more
core  

Construction of a genetic AND gate under a new standard for assembly of genetic parts

BMC Genomics, 2010
Background Appropriate regulation of respective gene expressions is a bottleneck for the realization of artificial biological systems inside living cells. The modification of several promoter sequences is required to achieve appropriate regulation of the
Hagiya Masami, Sakakibara Yasubumi, Murata Satoshi, Yugi Katsuyuki, Uchiyama Masahiko, Hamada Shogo, Takagi Hidemasa, Nakashima Yusaku, Kobayashi Akio, Ayukawa Shotaro, Yamamura Masayuki, Kiga Daisuke   +11 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Differentiable Set Operations for Algebraic Expressions

CoRR, 2019
11 pages, 12 ...
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Construction Theorem and Application of a Semi-Discrete Hilbert-Type Inequality Involving Partial Sums and Variable Upper Limit Integral Functions

Axioms
By using the construction theorem of semi-discrete Hilbert-type inequalities with quasi-homogeneous kernels and real analysis techniques, this paper establishes a semi-discrete Hilbert-type inequality involving partial sums and variable upper limit ...
Yong Hong, Bing He, Qian Zhao
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

First-order selfadjoint singular differential operators in a Hilbert space of vector functions

Electronic Journal of Differential Equations, 2017
In this article, we give a representation of all selfadjoint extensions of the minimal operator generated by first-order linear symmetric multipoint singular differential expression, with operator coefficient in the direct sum of Hilbert spaces of ...
Pembe Ipek, Bulent Yilmaz, Zameddin I. Ismailov   +2 more
doaj