Results 91 to 100 of about 108,839 (264)
Differentiable Set Operations for Algebraic Expressions
CoRR, 2019 11 pages, 12 ...
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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First-order selfadjoint singular differential operators in a Hilbert space of vector functions
Electronic Journal of Differential Equations, 2017 In this article, we give a representation of all selfadjoint extensions of the minimal operator generated by first-order linear symmetric multipoint singular differential expression, with operator coefficient in the direct sum of Hilbert spaces of ...
Pembe Ipek +2 more
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AxiomsBy using the construction theorem of semi-discrete Hilbert-type inequalities with quasi-homogeneous kernels and real analysis techniques, this paper establishes a semi-discrete Hilbert-type inequality involving partial sums and variable upper limit ...
Yong Hong, Bing He, Qian Zhao
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Selfadjoint extensions of multipoint singular differential operators
Electronic Journal of Differential Equations, 2013 This article describes all selfadjoint extensions of the minimal operator generated by a linear singular multipoint symmetric differential-operator expression for first order in the direct sum of Hilbert spaces of vector-functions.
Zameddin I. Ismailov
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
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On expressibility of non-monotone operators in SPARQL [PDF]
, 2016 SPARQL, a query language for RDF graphs, is one of the key technologies for the Semantic Web. The expressivity and complexity of various fragments of SPARQL have been studied extensively. It is usually assumed that the optional matching operator OPTIONAL has only two graph patterns as arguments.
Kontchakov, R, Kostylev, E
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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