Results 91 to 100 of about 4,067 (213)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Construction Theorem and Application of a Semi-Discrete Hilbert-Type Inequality Involving Partial Sums and Variable Upper Limit Integral Functions

open access: yesAxioms
By using the construction theorem of semi-discrete Hilbert-type inequalities with quasi-homogeneous kernels and real analysis techniques, this paper establishes a semi-discrete Hilbert-type inequality involving partial sums and variable upper limit ...
Yong Hong, Bing He, Qian Zhao
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

First-order selfadjoint singular differential operators in a Hilbert space of vector functions

open access: yesElectronic Journal of Differential Equations, 2017
In this article, we give a representation of all selfadjoint extensions of the minimal operator generated by first-order linear symmetric multipoint singular differential expression, with operator coefficient in the direct sum of Hilbert spaces of ...
Pembe Ipek   +2 more
doaj  

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Selfadjoint extensions of multipoint singular differential operators

open access: yesElectronic Journal of Differential Equations, 2013
This article describes all selfadjoint extensions of the minimal operator generated by a linear singular multipoint symmetric differential-operator expression for first order in the direct sum of Hilbert spaces of vector-functions.
Zameddin I. Ismailov
doaj  

On expressibility of non-monotone operators in SPARQL [PDF]

open access: yes, 2016
SPARQL, a query language for RDF graphs, is one of the key technologies for the Semantic Web. The expressivity and complexity of various fragments of SPARQL have been studied extensively. It is usually assumed that the optional matching operator OPTIONAL has only two graph patterns as arguments.
Kontchakov, R, Kostylev, E
openaire   +2 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

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