Results 31 to 40 of about 4,067 (213)

A Novel Immune-Related Prognostic Signature for Thyroid Carcinoma

Technology in Cancer Research & Treatment, 2020
Background: Recent studies have confirmed that immune-associated genes perform a crucial function in recurrence and metastasis of thyroid carcinoma. A reliable immune-related prognostic signature for patients with thyroid cancer is needed.
Yuanbo Xue MD, Jing Li MD, Xiubo Lu MD
doaj   +1 more source

Hyponormal differential operators with discrete spectrum [PDF]

Opuscula Mathematica, 2010
In this work, we first describe all the maximal hyponormal extensions of a minimal operator generated by a linear differential-operator expression of the first-order in the Hilbert space of vector-functions in a finite interval.
Zameddin I. Ismailov, Erdal Unluyol
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multipoint normal differential operators of first order [PDF]

Opuscula Mathematica, 2009
In this paper we discuss all normal extensions of a minimal operator generated by a linear multipoint differential-operator expression of first order in the Hilbert space of vector-functions on the finite interval in terms of boundary and interior point ...
Zameddin I. Ismailov
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Some Spectral Problems for First-Order Normal Differential Operators in the Weighted Hilbert Spaces of Vector Functions

Mathematics
In this article, in order for the minimal operator generated by the first-order differential-operator expression in the weighted Hilbert space of vector functions in the finite interval to be formal normal, the relationship between the variable operator ...
Zameddin I. Ismailov, Pembe Ipek Al, Mohammad Sababheh   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Sentenças genericamente quantificadas e expressões de referência a espécies no português brasileiro

Cadernos de Estudos Lingüísticos, 2012
This article investigates the expression of genericity in Brazilian Portuguese. Its theoretical background is the analysis of kind referring expressions as proper names of kinds (cf.
Ana Müller
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source