Results 61 to 70 of about 773,316 (284)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
New versions of refinements and reverses of Young-type inequalities with the Kantorovich constant
Special Matrices, 2023 Recently, some Young-type inequalities have been promoted. The purpose of this article is to give further refinements and reverses to them with Kantorovich constants.
Rashid Mohammad H. M., Bani-Ahmad Feras
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Norm Estimates for Solutions of Polynomial Operator Equations
Journal of Mathematics, 2015 We consider the equations ∑k=0mcm-kAkXBk=C and ∑k=0mcm-kAkXBm-k=C, where ck∈C (k=1,…,m), c0=1, A,B,C are given linear bounded operators in a Banach space and X is to be found. Representations of solutions are derived.
Michael Gil’
doaj +1 more source
Range-kernel weak orthogonality of some elementary operators
Open Mathematics, 2021 We study the range-kernel weak orthogonality of certain elementary operators induced by non-normal operators, with respect to usual operator norm and the Von Newmann-Schatten pp-norm (1 ...
Bachir Ahmed +2 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A sufficient condition for the boundedness of operator-weighted martingale transforms and Hilbert transform [PDF]
, 2007 Let W be an operator weight taking values almost everywhere in the bounded positive invertible linear operators on a separable Hilbert space H. We show that if W and its inverse W−1 both satisfy a matrix reverse Holder property introduced in [2], then ...
Pott, S.
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source