Results 81 to 90 of about 25,259 (306)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Learning neural operators on Riemannian manifolds
National Science OpenLearning mappings between functions (operators) defined on complex computational domains is a common theoretical challenge in machine learning. Existing operator learning methods mainly focus on regular computational domains, and have many components ...
Chen Gengxiang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Upper Bounds for the Euclidean Operator Radius and Applications
, 2006 The main aim of the present paper is to establish various sharp upper bounds for the Euclidean operator radius of an n−tuple of bounded linear operators on a Hilbert space.
Dragomir, Sever S
core
Norm estimates for operators in norm-attainable C*-algebras
European Journal of Mathematics and Applications, 2023 Norm estimates for various types of Banach algebra operators have been studied over decades with interesting results obtained. However, it still remains an open problem to determine the norm of an operator in a general Banach space setting. In this note,
Sabasi Omaoro +2 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A General Norm on Extension of a Hilbert’s Type Linear Operator
Journal of Mathematical Extension, 2010 The main purpose of this paper is to study a general norm on extension of a Hilbert’s type linear operator in the continuous and discrete form. In addition to expressing the norm of a Hilbert’s type linear operator T : L 2 (0,∞) → L 2 (0,∞), a ...
Z. Jokar, J. Behboodian
doaj
On the Norm of Certain Weighted Composition Operators on the Hardy Space
Abstract and Applied Analysis, 2009 We obtain a representation for the norm of certain compact weighted composition operator 𝐶𝜓,𝜑 on the Hardy space 𝐻2, whenever 𝜑(𝑧)=𝑎𝑧+𝑏 and 𝜓(𝑧)=𝑎𝑧−𝑏. We also estimate the norm and essential norm of a class of noncompact weighted composition operators ...
M. Haji Shaabani, B. Khani Robati
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Norm Bounds for Operator Extensions
Journal of Mathematical Analysis and Applications, 1995 Consider the partial \(n\times n\) matrix \(F\) with bounded Hilbert space operator entries, where the lower triangular entries are specified and the strictly upper triangular entries are to be determined. Any choice of the strictly upper triangular entries provides a completion or extension of \(F\).
Bakonyi, M. +3 more
openaire +1 more source