Results 41 to 50 of about 205,748 (273)

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR [PDF]

, 2008
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream
Shivanthi Samarasinghe, Mohamed Samir El-Robh, David C. Grainger, Wenke Zhang, Panos Soultanas, Stephen J. W. Busby, Gralla, Choy, Rojo, Schleif, Schleif, Gallegos, Webster, Belyaeva, Wade, Webster, Webster, Michán, Kahramanoglou, Tobes, Martin, Grainger, Wade, Lodge, Williams, Grainger, Kolb, Perrin, Miller, Caswell, Hansma, Ishihama, Lee, Meares, Virnik, Wang, Zhang, Bourgerie, Semsey, Roy, Plumbridge, Kachroo   +41 more
core   +4 more sources

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

The Rhizobium etli trpB Gene Is Essential for an Effective Symbiotic Interaction with Phaseolus vulgaris

Molecular Plant-Microbe Interactions, 1999
A mutant strain (CTNUX4) of Rhizobium etli carrying Tn5 unable to grow with ammonium as the sole nitrogen source was isolated and characterized. Sequence analysis showed that Tn5 is inserted into a trpB (tryptophan synthase)-homologous gene.
Rosarita Taté, Anna Riccio, Emilia Caputo, Michele Cermola, Renee Favre, Eduardo J. Patriarca   +5 more
doaj   +1 more source

Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC [PDF]

, 2013
The temporal and cell density-dependent regulation of expression of virtually all the Staphylococcus aureus virulon is under the control of the agr (accessory gene regulatory) operon.
Edwards, AM, James, EH, Wigneshweraraj, S   +2 more
core   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

A transcription unit based systems biology study on Salmonella typhimurium gene organization, evolution, co-expression, and regulation

Frontiers in Microbiology
A bacterial transcription unit (TU) could be composed of a single gene or multiple adjacent genes forming an operon. Traditional systems biology often relies on gene-centric analysis, overlooking the regulatory complexity inherent in the operon structure,
Leting Sun, Zhixuan Deng, Junya Zhang, Xin Cao, Shuhong Liu, Runhong Chen, Min Zheng, Yejun Wang, Yejun Wang, Yejun Wang   +9 more
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state. [PDF]

PLoS Computational Biology, 2018
Within an isogenic population, even in the same extracellular environment, individual cells can exhibit various phenotypic states. The exact role of stochastic gene-state switching regulating the transition among these phenotypic states in a single cell ...
Hao Ge, Pingping Wu, Hong Qian, Xiaoliang Sunney Xie   +3 more
doaj   +1 more source

An open reading frame upstream from the nifH gene of Klebsiella pneumoniae [PDF]

, 1983
An open reading frame upstream from nifHDK operon of Klebsiella pneumoniae had been described. The orientation of this open reading frame is opposite to that of nifHDK and sequence homology was found between the open reading frame promoter and the ...
Kong, Qiu-tong, Shen, San-chiun, Wu, Qi-long, Xue, Zhong-tian   +3 more
core  

Boolean Models of Bistable Biological Systems

, 2009
This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model.
A. Novick, C. Conradi, E. Aurell, F. Jacob, L. Mendoza, M. Cohn, M. Ptashne, M. Santillán, N. Friedman, N. Yildirim, P. Wong, R. Albert, R. de Boer, R. Edwards, R. Laubenbacher, S. A. Kauffman, T. Tian   +16 more
core   +1 more source