Ophthalmic Drug Dosage Forms: Characterisation and Research Methods
The Scientific World Journal, 2014 This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties.
Przemysław Baranowski +3 more
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Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]
, 2017 The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico +5 more
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International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective The aim of the present study was to analyze breastfeeding rates and duration in relation to preterm birth, fetal growth restriction, and demographics over five decades. Methods This retrospective cohort study included 1559 individuals (aged 4–52 years) and their parents from the University Medical Center Mainz, Germany.
Achim Fieß +10 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Introduction Pre‐eclampsia (PE) involves systemic endothelial dysfunction and microvascular injury, yet routine obstetric care lacks noninvasive readouts of maternal microvascular health. We evaluated whether hypertensive retinopathy (HR) detected during pregnancy is associated with maternal disease severity and adverse neonatal outcomes ...
Gabriele Saccone +6 more
wiley +1 more source
The Role of Xenobiotic Transporters in Ophthalmic Drug Delivery
Journal of Pharmacy & Pharmaceutical Sciences, 2013 The eye is a very complex sensory organ consisting of numerous structures to coordinate the function of sight. It has a series of physical and chemical barriers to help maintain its homeostasis, and mediate environmental exposures.
Nagendra Chemuturi, Jaime A Yanez
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The adenylate cyclase receptor complex and aqueous humor formation. [PDF]
, 1984 The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
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Acetic and Acrylic Acid Molecular Imprinted Model Silicone Hydrogel Materials for Ciprofloxacin-HCl Delivery [PDF]
, 2012 Hui, A., Sheardown, H., & Jones, L. (2012). Acetic and Acrylic Acid Molecular Imprinted Model Silicone Hydrogel Materials for Ciprofloxacin-HCl Delivery. Materials, 5(12), 85–107.
Hui, Alex +2 more
core +2 more sources
Interdisciplinary Medicine, EarlyView.Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui +12 more
wiley +1 more source
Design and Development of Antibacterial/Anti-inflammatory Dual Drug-Loaded Nanofibrous Inserts for Ophthalmic Sustained Delivery of Gentamicin and Methylprednisolone: In Vitro Bioassay, Solvent, and Method Effects’ Evaluation [PDF]
, 2021 Shahla Mirzaeei, Donya Barfar
openalex +1 more source
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
core +3 more sources