Results 71 to 80 of about 21,086 (303)

Retinitis Pigmentosa‐Associated Gene TRIM49 Regulates ULK1‐Mediated Autophagy and Photoreceptor Phagocytosis by the Retinal Pigment Epithelium

Advanced Science, EarlyView.
Based on next‐generation sequencing data of retinitis pigmentosa (RP) patients and controls, this study identifies TRIM49 as a novel gene for autosomal recessive RP. TRIM49 is specifically expressed in the retinal pigment epithelium (RPE) of human retina.
Zhen Yi, Chaojuan Wen, Han Du, Yingwei Wang, Shuowei Chen, Jie Liu, Shuhan Zhang, Junwen Wang, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Yi Jiang, Jiamin Ouyang, Panfeng Wang, James Fielding Hejtmancik, Wenmin Sun, Huangxuan Shen, Qingjiong Zhang   +17 more
wiley   +1 more source

Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits

Ophthalmology and Therapy, 2019
Introduction Brimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues ...
Keisuke Shinno, Kazuya Kurokawa, Seiko Kozai, Akio Kawamura, Katsuhiro Inada, Hideki Tokushige   +5 more
doaj   +1 more source

A Pill That Prints‐An Ingestible Bioprinter for Non‐Invasive Structured Bioink Deposition

Advanced Science, EarlyView.
A first‐of‐a‐kind swallowable bioprinter performs in‐situ bioink deposition and patterning directly over disease sites without tethers, electronics, or invasive surgery. Combining magnetic guidance with near‐infrared triggering enables functionality within a small footprint.
Sanjay Manoharan, Vivek Subramanian
wiley   +1 more source

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, EarlyView.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source

Topical ophthalmic antimicrobials: unfulfilled demands and possibility of new investments in Brazil and in the United States

Brazilian Journal of Pharmaceutical Sciences, 2019
In general, topical ophthalmic drug products, especially those used for treating infections, present low effectiveness because of various reasons, from unfavorable drug physicochemical properties to physiological protective mechanisms of the eye.
Bianca Kollross, Guilherme Martins Gelfuso, Marcilio Cunha-Filho, Tais Gratieri   +3 more
doaj   +1 more source

Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology

Advanced Intelligent Systems, EarlyView.
This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin, Lei Wang, Shanjun Wu, Jiewei Jiang, Wei Qiang, Yangyang Wang, Shihong Wang, Yi Shao, Wei Chen, Zhongwen Li   +9 more
wiley   +1 more source

Development and evaluation of a chloramphenicol hypertonic ophthalmic solution

Indian Journal of Pharmaceutical Sciences, 2008
Hypertonic ophthalmic solutions are used to treat ocular diseases associated with edema. In this study, we developed a chloramphenicol hypertonic ophthalmic solution. These drops were developed based on the cosolvency and additional dielectric constant concepts. Two different solvents: PEG 300 and glycerol were used as cosolvents.
AV Jithan, M Vimaladevi, C Krishna Mohan
openaire   +4 more sources

Intestinal Atresia in PPP1R12A‐Related Urogenital and Brain Malformation Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT PPP1R12A‐related urogenital and brain malformation syndrome (UBMS) is a newly described disorder characterized by congenital anomalies primarily involving the urogenital system and the brain. We describe a preterm female neonate with multiple congenital anomalies, including type IIIb jejunal atresia, incomplete intestinal rotation, imperforate
Adriana Gomes, Sanjana Karamcheti, Álvaro Martín Rodriguez, Anna‐Kaisa Niemi, Lynne M. Bird   +4 more
wiley   +1 more source

Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation. [PDF]

Pharm Res, 2023
Le Merdy M, AlQaraghuli F, Tan ML, Walenga R, Babiskin A, Zhao L, Lukacova V.   +6 more
europepmc   +1 more source

Biocompatibility of the Polymer Poly(Butylene Adipate‐Co‐Terephthalate) in the Cornea of Rabbits

Journal of Applied Polymer Science, EarlyView.
The biocompatibility of the PBAT in the rabbit cornea was evaluated through clinical assessment and histopathological analysis using hematoxylin and eosin, picrosirius red, and Masson’s trichrome staining. ABSTRACT In a novel approach to corneal biomaterials, this study evaluated the biocompatibility of heat‐pressed poly(butylene adipate‐co ...
Aline C. Pereira, Giovanna G. Rodrigues, Juliana T. Wagatsuma, Maria Cecília R. Luvizotto, Alessandra A. Lucas, Pedro Henrique C. Oliveira, Flávio D. Faria, Luciano T. A. Cintra, Alexandre L. Andrade   +8 more
wiley   +1 more source